The Bitter Pill

The Official Blog of UNITE – uniteforlife.org

PsychRights Argues For Pro Bono Movement

A call for attorneys in New York – a memo on “Kendra’s Law”

This is a fascinating read detailing all the reasons why we need attorneys in each judicial district to step up to the plate and defend patients against forced drugging. As Gottstein states, his memo does not fully address the crisis of forced ECT, or the mass drugging of America’s children, which is clearly an emergency. 

But obviously the time could not be more appropriate to defend adults against forced drugging. We are faced, after all, with the possibility of forced drugging via The MOTHERS Act. I can’t imagine anything worse than drugging mothers, especially when these mothers are or become pregnant while on drugs. To drug unborn babies should be classified as criminal, but presently it is revered by the completely unethical mental ‘health’ community. This absurd and deluded group of people actually argues that the benefits of medication outweigh the risk to the unborn or newborn baby. 

Let’s compare the benefits to the risks.

  • Antidepressants (stimulants in the same category as LSD and cocaine): proven no more effective than a placebo.
    Risks/effects: suicide, homicide, stillbirth, spontaneous abortion, fatal birth defects, SIDS, psychosis, diabetes, coma, death via serotonin syndrome…
  • Mood stabilizers (anticonvulsants): Benefits? Perhaps prevention of seizures caused by antidepressants (stimulants)
    Risk: double the rate of suicide according to the latest data…
  • ‘Antipsychotics’ (misnamed, actually neruoleptics in the same class as rat poison): Benefits? You will sleep more, because you will be asleep most of the time (potentially involuntarily when the nurse gives you a shot in the behind)…
    Risk of death increased by a rate of 2.5 per increment of neuroleptic, with long-term use, shave off 25 years from your life. Evidence that these drugs are actually PRO-psychotics.

Please read the memo by Gottstein and the attached affidavits by Whittaker and Jackson. Here is a snippet:

(a) Neuroleptics dramatically increase the likelihood that a person will become chronically  disabled.  

(b) Long-term recovery rates are much higher for unmedicated patients than for those who are maintained on neuroleptic drugs. 

(c) Neuroleptics cause a host of debilitating physical, emotional and cognitive negative effects, including substantial brain damage, and lead to early death. 

(d) The new “atypical” neuroleptics are not better than the old ones in terms of their safety and tolerability, and quality of life may even be worse on the new drugs than on the old ones.  

III. Involuntary Administration of Neuroleptics is Experienced as Torture by Many…

Filed under: antipsychotics, Congress, forced 'treatment', Jim Gottstein, mothers act, Paxil in pregnancy, PsychRights, seizures, suicide, toxicity deaths, , , , ,

Seizures Induced With Wellbutrin

Paragraphs 5 through 7 read: “Results: The results show that administration of IP bupropion HCl [Wellbutrin] alone induced seizures in mice in a dose-dependent manner, with the 120 mg/kg dose having the largest effect. The percentage of convulsing mice were 0%, 20%, 30% and 60% in the 0 (vehicle), 100, 110, and 120 mg/kg dose groups, respectively.”Pretreatment with ethanol produced a larger bupropion HCl-induced convulsive effect at all the doses (70% each at 100, 110 and 120 mg/kg) and a 10% effect in the ethanol + vehicle only group. The convulsive dose of bupropion HCl required to induce seizures in 50% of mice (CD50), was 116.72 mg/kg for bupropion HCl alone (CI: 107.95, 126.20) and 89.40 mg/kg for ethanol/bupropion HCl (CI: 64.92, 123.10).”

“Conclusions: These results show that in mice alcohol lowers the seizure threshold for bupropion [Wellbutrin] -induced seizures.”

Click here for the original story.

Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol, even when advised not to.

Previous studies have not shown any interactions between bupropion HCl and alcohol. However, there have been no previous studies examining possible changes in seizure threshold induced by a combination of alcohol and bupropion HCl.

Methods: Experimentally naive female Swiss albino mice (10 per group) received either single doses of bupropion HCl (ranging from 100 mg/kg to 120 mg/kg) or vehicle (0.9% NaCl) by intraperitoneal (IP) injection in a dose volume of 10 ml/kg, and single-dose ethanol alone (2.5 g/kg), or vehicle, 5 min prior to bupropion dosing.

The presence or absence of seizures, the number of seizures, the onset, duration and the intensity of seizures were all recorded for 5 h following the administration of ethanol.

Results: The results show that administration of IP bupropion HCl alone induced seizures in mice in a dose-dependent manner, with the 120 mg/kg dose having the largest effect. The percentage of convulsing mice were 0%, 20%, 30% and 60% in the 0 (vehicle), 100, 110, and 120 mg/kg dose groups, respectively.

Pretreatment with ethanol produced a larger bupropion HCl-induced convulsive effect at all the doses (70% each at 100, 110 and 120 mg/kg) and a 10% effect in the ethanol + vehicle only group. The convulsive dose of bupropion HCl required to induce seizures in 50% of mice (CD50), was 116.72 mg/kg for bupropion HCl alone (CI: 107.95, 126.20) and 89.40 mg/kg for ethanol/bupropion HCl (CI: 64.92, 123.10).

Conclusions: These results show that in mice alcohol lowers the seizure threshold for bupropion-induced seizures.

Clinical implications are firstly that there may be an increased risk of seizures in patients consuming alcohol, and secondly that formulations that can release bupropion more readily in alcohol may present additional risks to patients.

Author: Peter H Silverstone, Robert Williams, Louis McMahon, Rosanna Fleming and Siobhan Fogarty
Credits/Source: Annals of General Psychiatry 2008, 7:11

Filed under: seizures, Wellbutrin

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